The Multifaceted Role of Endothelial Sirt1 in Vascular Aging: An Update
NAD+-dependent deacetylase sirtuin-1 (Sirt1) belongs to the sirtuins family, known to be longevity regulators, and exerts a key role in the 50"x60" prevention of vascular aging.By aging, the expression levels of Sirt1 decline with a severe impact on vascular function, such as the rise of endothelial dysfunction, which in turn promotes the developme